Decoding the Mechanisms Underlying Susceptibility to Neurodegeneration with iPSC-Derived Human

In this talk, Dr. Joel W. Blanchard will highlight three examples of this approach:

• How a rare genetic mutation drives severe juvenile PD, revealing a lysosome–polyamine–epigenetic axis of neurodegeneration.

• How APOE4 promotes α-synuclein co-pathology through glial dysfunction.

• How APOE4 drives cerebrovascular remodeling and blood–brain barrier dysfunction in AD.

https://neuros.creative-biolabs.com/decoding-the-mechanisms-underlying-susceptibility.htm