As nucleic acid therapeutics advance, researchers increasingly need tools that provide more than confirmation of target engagement or tissue exposure. Understanding the localization and distribution of modified oligonucleotides across cells, tissues and biological compartments, as well as how these patterns relate to biological activity can provide critical insights into therapeutic development. Advanced imaging approaches allow researchers to visualize these molecules in their biological context and investigate questions beyond traditional quantitative measurements.
This webinar will explore how antibody-based detection methods and advanced microscopy technologies can be combined to visualize and characterize nucleic acid therapeutics in biological samples. Attendees will learn how these complementary approaches provide insights into cellular uptake, tissue distribution and localization patterns, deepening the understanding of therapeutic behavior.
The first presentation will highlight how advanced imaging technologies address challenges in oncology research, from investigating disease biology to generating quantitative insights from biological samples. Through application-focused examples, attendees will explore how complementary imaging and analysis approaches support image acquisition, data interpretation and biological discovery. The session will also discuss how specialized microscopy capabilities and scientific expertise support complex biological research.
The second presentation will examine how modification-specific antibodies detect chemically modified oligonucleotides across therapeutic modalities. Through published research and examples involving diffuse midline glioma, attendees will explore how these antibodies can be used in imaging workflows to visualize nucleic acid therapeutics in cell-based and
in vivo
models. The discussion will highlight applications in cellular uptake and biodistribution studies, along with considerations for interpreting detection patterns and imaging results.
Register for this webinar to learn how antibody-based detection and advanced imaging techniques can improve the visualization and characterization of nucleic acid therapeutics in biological samples.
Who Should Attend
This webinar is intended for scientists and research professionals interested in imaging nucleic acids and investigating complex biological samples, including:
Nucleic Acid and Oligonucleotide Therapeutic Researchers
Cancer Biologists and Oncology Researchers
Cell and Molecular Biologists
Drug Delivery and Preclinical Research Scientists
Microscopy, Imaging and Image Analysis Specialists
Translational Researchers
Register free on Xtalks: https://xtalks.com/webinars/advances-in-nucleic-acid-therapeutics-detection-and-biological-imaging-broadcast-2/
